EVALUATION OF THE DIAGNOSTIC ACCURACY OF TWO AI MODELS FOR ANALYZING MAMMOGRAPHIC IMAGES
DOI:
https://doi.org/10.17770/etr2025vol2.8572Keywords:
artificial intelligence, ChatGPT, mammography, X-Ray InsightAbstract
Early diagnosis of breast cancer is crucial for improving prognosis and reducing mortality. Mammographic screening is a standard method for detecting malignant lesions, but its effectiveness depends on accurate interpretation and clear communication with patients. In recent years, artificial intelligence (AI) has shown promising results in medical diagnostics, yet its ability to analyze mammographic images and provide reliable patient guidance remains insufficiently studied. This pilot study evaluates the diagnostic accuracy and informational quality of two AI models—ChatGPT and X-Ray Insight. To assess their performance, we use a standardized database of mammographic images, including benign and malignant findings. Additionally, patient inquiry scenarios are used to evaluate the AI-generated explanations, recommendations, and overall clarity in response to common patient concerns. The results are compared against expert radiologist assessments. The AI models are evaluated based on diagnostic accuracy, clarity and correctness of explanations, usefulness of recommendations, and potential risks. Both models performed equally in determining the BI-RADS category, Differential Diagnosis, and Next Clinical Steps. The study underscores the challenges of integrating generative AI models into medical diagnostics, revealing both accurate insights and notable inaccuracies compared to expert interpretations. These discrepancies highlight the need for further training and refinement to improve the reliability and applicability of AI in clinical settings.
References
G. Dimitrov, I. Gavrilov, and T. Sedloev, Eds., Breast Cancer. Paradigm, 2014.
V. Parvanova, Breast Cancer - Early Detection and Modern Treatment, Sofia: Tip - Top Press, 2006.
T. Deliyski and D. Damyanov, Recommendations for Complex Treatment of Breast Cancer, Pleven: University Hospital-Pleven EAD, 2005.
N. Day and R. Warren, "Mammographic screening and mammographic patterns," Breast Cancer Res., vol. 2, no. 4, pp. 247-251, 2000, doi: 10.1186/bcr64.
E. U. Ekpo, M. Alakhras, and P. Brennan, "Errors in Mammography Cannot be Solved Through Technology Alone," Asian Pac. J. Cancer Prev., vol. 19, no. 2, pp. 291-301, 2018, doi: 10.22034/APJCP.2018.19.2.291.
Y. Eneva and B. Dogan, "A Qualitative Assessment of Medical Diagnosis Capabilities of Three Artificial Intelligence Models: ChatGPT-4o, CodyMD, and Dr. Gupta," J. Biosci. Med., vol. 12, pp. 243-254, 2024, doi: 10.4236/jbm.2024.1211021.
Y. Eneva and B. Dogan, "Evaluation of Medical Diagnosis Capabilities of Three Artificial Intelligence Models – ChatGPT-3.5, Google Gemini, Microsoft Copilot: Sustainable Development Goals (SDGs)," J. Lifestyle and SDGs Review, vol. 5, no. 2, e03545, 2025, doi: 10.47172/2965-730X.SDGsReview.v5.n02.pe03545.
D. Killock, "AI outperforms radiologists in mammographic screening," Nat. Rev. Clin. Oncol., vol. 17, no. 3, p. 134, 2020, doi: 10.1038/s41571-020-0329-7.
S. Al Muhaisen, O. Safi, A. Ulayan, et al., "Artificial Intelligence-Powered Mammography: Navigating the Landscape of Deep Learning for Breast Cancer Detection," Cureus, Mar. 2024, doi: 10.7759/cureus.56945.
Radiopaedia.org, "The peer-reviewed collaborative Radiology Resource," [Online]. Available: https://radiopaedia.org/. [Accessed: Mar. 1, 2025].
H. Al Ja’afreh, "Invasive ductal carcinoma," Case study, Radiopaedia.org, [Online]. Available: https://doi.org/10.53347/rID-174470. [Accessed: Feb. 3, 2025].
A. Ashraf, "Giant fibroadenoma," Case study, Radiopaedia.org, [Online]. Available: https://doi.org/10.53347/rID-90946. [Accessed: Feb. 3, 2025].
W. Lee, "Ductal carcinoma in situ," Case study, Radiopaedia.org, [Online]. Available: https://doi.org/10.53347/rID-160609. [Accessed: Feb. 3, 2025].
A. Ruiz Gaviria, "Breast abscess - male," Case study, Radiopaedia.org, [Online]. Available: https://doi.org/10.53347/rID-163546. [Accessed: Feb. 3, 2025].
V. Pai, "Hamartoma of the breast," Case study, Radiopaedia.org, [Online]. Available: https://doi.org/10.53347/rID-27023. [Accessed: Feb. 7, 2025].
M. Altintakan, "Multiple fibroadenomas and fibrocystic disease," Case study, Radiopaedia.org, [Online]. Available: https://doi.org/10.53347/rID-75028. [Accessed: Feb. 7, 2025].
M. Niknejad, "Multifocal breast cancer - 2D mammography and tomosynthesis," Case study, Radiopaedia.org, [Online]. Available: https://doi.org/10.53347/rID-156732. [Accessed: Feb. 7, 2025].
A. Abougazia, "Gynaecomastia," Case study, Radiopaedia.org, [Online]. Available: https://doi.org/10.53347/rID-23657. [Accessed: Feb. 7, 2025].
A. Ashraf, "Gigantomastia," Case study, Radiopaedia.org, [Online]. Available: https://doi.org/10.53347/rID-150940. [Accessed: Feb. 7, 2025].
W. Lee, "Invasive solid papillary carcinoma of the breast," Case study, Radiopaedia.org, [Online]. Available: https://doi.org/10.53347/rID-161313. [Accessed: Feb. 7, 2025].
A. Ashraf, "Malignant phyllodes tumour," Case study, Radiopaedia.org, [Online]. Available: https://doi.org/10.53347/rID-89374. [Accessed: Feb. 7, 2025].
S. Sorrentino, "Invasive lobular carcinoma," Case study, Radiopaedia.org, [Online]. Available: https://doi.org/10.53347/rID-34821. [Accessed: Feb. 8, 2025].
A. Ranchod, "Plasma cell mastitis," Case study, Radiopaedia.org, [Online]. Available: https://doi.org/10.53347/rID-175533. [Accessed: Feb. 8, 2025].
I. Khatatbeh, "Invasive breast carcinoma," Case study, Radiopaedia.org, [Online]. Available: https://doi.org/10.53347/rID-190669. [Accessed: Feb. 8, 2025].
N. Abidin, "Diabetic mastopathy," Case study, Radiopaedia.org, [Online]. Available: https://doi.org/10.53347/rID-58607. [Accessed: Feb. 8, 2025].
G. Kruger, "Nerve sheath tumour - breast," Case study, Radiopaedia.org, [Online]. Available: https://doi.org/10.53347/rID-18778. [Accessed: Feb. 8, 2025].
H. Knipe, "Axillary tail breast cancer," Case study, Radiopaedia.org, [Online]. Available: https://doi.org/10.53347/rID-43262. [Accessed: Feb. 9, 2025].
A. Abdelrahman, "Triple negative breast cancer," Case study, Radiopaedia.org, [Online]. Available: https://doi.org/10.53347/rID-78448. [Accessed: Feb. 9, 2025].
G. Kruger, "Surgical scar of the breast," Case study, Radiopaedia.org, [Online]. Available: https://doi.org/10.53347/rID-22389. [Accessed: Feb. 9, 2025].
G. Baratelli, "Non-Hodgkin lymphoma arising from an intramammary lymph node," Case study, Radiopaedia.org, [Online]. Available: https://doi.org/10.53347/rID-42463. [Accessed: Feb. 9, 2025].
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Bora Dogan, Yanka Baneva, Yordanka Eneva, Elena Ivanova

This work is licensed under a Creative Commons Attribution 4.0 International License.